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Sunday, August 9, 2020 | History

2 edition of disposition of ARA-C and its metabolites found in the catalog.

disposition of ARA-C and its metabolites

P. F. Morrison

disposition of ARA-C and its metabolites

a pharmacokinetic simulation

by P. F. Morrison

  • 98 Want to read
  • 2 Currently reading

Published by Rand in Santa Monica .
Written in English

    Subjects:
  • Leukemia -- Chemotherapy.,
  • Antineoplastic agents.

  • Edition Notes

    Other titlesARA-C and its metabolites ...
    StatementP.F. Morrison, T.L. Lincoln, J. Aroesty.
    Series[Report] - Rand Corporation ; R-1757-NIH
    ContributionsLincoln, Thomas L.. joint author., Aroesty, Jerome. joint author., Rand Corporation., National Institutes of Health (U.S.)
    The Physical Object
    Paginationix, 37 p. ;
    Number of Pages37
    ID Numbers
    Open LibraryOL16474483M

    MASS SPECTROMETRY IN THE QUANTITATIVE ANALYSIS OF THERAPEUTIC INTRACELLULAR NUCLEOTIDE ANALOGS Robert S. Jansen,1* Hilde Rosing,1 Jan H.M. Schellens,2,3 and Jos H. Beijnen1,3 1 Department of Pharmacy & Pharmacology, Slotervaart Hospital/ The Netherlands Cancer Institute, Louwesweg 6, EC Amsterdam, the Netherlands 2 Department of Clinical . Summary. l-(2’-Deoxy-2’-fluoro-β-D-arabinofuranosyl)iodocytosine [FIAC or 2’-fluoroiodo-ara-C] is a potent and selective new anti-herpes virus jydrescueteam.com anti-herpes simplex virus type 1 (HSV-1) activity depends, at least in part, on the phosphorylation of FIAC by Author: Carlos Lopez, Ting-Chao Chou, Kyoichi A. Watanabe, Jack J. Fox.

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Disposition of ARA-C and its metabolites by P. F. Morrison Download PDF EPUB FB2

Note: Citations are based on reference standards. However, formatting rules can vary widely between applications and fields of interest or study. The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied.

Country of Publication: United States Publisher: Santa Monica: Rand Corp., Description: ix, 37 p.: ill. Language: English MeSH: Cytarabine/pharmacology*; Models, Biological* Notes: "RNIH." Supported by the National Institutes of Health under grants 2 RO1 CA and 5 RO1 CA NLM ID: [Book].

Ara-C: Cellular and Molecular Pharmacology B. Phosphorylation Once inside the cell, ara-C is converted to its nucleoside monophosphate derivative, ara-CMP, by the pyrimidine salvage pathway enzyme, deoxycyti- dine kinase (dCK).

This process represents the rate-limiting step in ara-C me- tabolism (Plagemann etal., ; Kufe and Spriggs, ).Cited by: In book: Modelling Optimization and Control of Biomedical Systems, pp The Disposition of Ara-C and Its Metabolites: A Pharmacokinetic Simulation.

Book. and cytarabine (Ara-C) [1. The initial plasma half-life of ara-C has been estimated to be 10–12 minutes. Approximately 90% of the administered ara-C dose is excreted by the kidneys as ara-U or other inactive metabolites. Disposition of ARA-C and its metabolites book terminal half-life of ara-C is approximately 2–3 hours.

CNS ara-C levels after a 2-hour infusion approximate 50% of plasma concentrations. The clinical pharmacokinetics of teniposide (VM, NSC ) has been studied in 21 children (median age, years) with acute lymphocytic leukemia.

Abstract. A physiologically based pharmacokinetic model for diazepam disposition was developed in the rat, incorporating anatomical, physiological, and biochemical parameters, i.e., tissue volume, blood flow rate, serum free fraction, distribution of diazepam into red blood cells, drug metabolism and tissue-to-blood distribution jydrescueteam.com by: Gemcitabine is a cytosine analogue and intravenously administered antineoplastic agent used in the therapy of several forms of advanced, pancreatic, lung, breast, ovarian and bladder cancer.

Gemcitabine is associated with a high rate of transient serum enzyme elevations during therapy but is a very rare cause of acute, clinically apparent liver injury. You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read.

Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. Ings RM, Fillastre JP, Godin M, Leroy A, Humbert G: The pharmacokinetics of cefotaxime and its metabolites in subjects with normal and impaired renal fuction.

Rev Infect Dis 4 (Suppl):S, PubMed CrossRef Google Scholar. (BQ) Part 2 book Modelling optimization and control of biomedical systems has contents: An integrated platform for the study of leukaemia, in silico acute myeloid leukaemia, in vitro studies - acute myeloid leukaemia, and other contents.

0 Time. Arabinosylcytosine (l-β-D-arabinofuranosylcytosine; cytosine arabinoside; cytarabine; ara C) belongs to a class of nucleosides with D-arabinose as the pentose sugar moiety. The inversion of the 2′-hydroxyl group as compared with ribonucleosides (Fig. 1) conveys markedly different properties, and in many respects the arabinosides are.

Nucleoside analog, cytarabine (ara-C) is the mainstay of acute myeloid leukemia (AML) chemotherapy. Cytarabine and other nucleoside analogs require activation to the triphosphate form (ara-CTP).

Intracellular ara-CTP levels demonstrate significant inter-patient variation and have been related to therapeutic response in AML patients.

Inter-patient variation in expression levels of drug Author: Neha S. Bhise, Abdelrahman H. Elsayed, Xueyuan Cao, Stanley Pounds, Jatinder K.

Lamba. Phenylacetylglutaminate (PG) and Phenylacetate (PN) are metabolites of Phenylbutyrate (PB) and are constituents of antineoplaston AS These are sodium salts of amino acid derivative and carboxylic acid that inhibit the growth of neoplastic cells without growth inhibitory effect in normal cells.

The aim of this study was to identify molecular pathways involved in the anti-proliferative Cited by: 4. Alberts DS, Peng Y-M, Leigh S.

et al. Disposition of mitoxantrone in cancer patients. (MITOX) and cytosine arabinoside (ARA-C) in acute non-lymphocytic leukemia (ANLL) and blast crisis of chronic Ueda K. et al.

Biliary excretion mechanism of CPT and its metabolites in humans: involvement of primary active transporters. Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF.

Visit jydrescueteam.com to get more information about this book, to buy it in print, or to download it as a free PDF. Patients with cancer often develop serious gram-negative bacterial infections. Since bacterial endotoxins have been shown to affect the in vitro hepatic metabolism of antineoplastic agents, significant infection may adversely affect drug pharmacokinetics and metabolism in these patients.

To evaluate the clinical significance of these effects, bacterial endotoxin ( mg/kg, IV) was Cited by: 6. Depocyt ® is a pyrogen-free, parenteral suspension of the antimetabolite Ara-C, developed for the treatment of neoplastic meningitis (NM) by controlled release of Ara-C.

Depocyt ® is a slow-release formulation developed by encapsulating the aqueous drug solution in multivesicular particles with a granular structure known as DepoFoam Cited by: and its metabolites in human liver microsomes by high-performance liquid chromatography.

Biomed. Chromatogr. 10, (). Vielnascher, M. Spatzenegger, A. Mayrhofer, P. Klinger W. Jäger*: Metabolism of dextromethorphan in human liver microsomes: a rapid HPLC assay to monitor cytochrome P 2D6 activity. Pharmazie 51, (). Amiodarone and its metabolites inhibit the metabolism of both R- and S-warfarin, but the metabolism of S-warfarin is more strongly inhibited.

Amiodarone inhibits CYP2C9 and also CYP3A4. Interactions may be seen as early as 4 to 6 days following the initial administration of the drugs in combination, or as delayed as weeks.

Abstract. Chemotherapy is currently a major component of the therapy for most disseminated pediatric cancers. Through the development of effective drugs and the optimal utilization of these agents, major advances have been achieved in the response rate, disease-free survival, and cure of several pediatric cancers, including acute lymphocytic leukemia and Hodgkin’s jydrescueteam.com: William E.

Evans, Clinton F. Stewart, Michael L. Christensen, William R. Crom.Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species.

PBPK modeling is used in pharmaceutical research and drug development, and in health risk assessment for cosmetics or general chemicals.Lokiec F, Canal P, Gay C, Chatelut E, Armand JP, Roche H, Hugat R, Goncalves E, and Matieu-Boue A. Pharmacokinetics of irinotecan and its metabolites in himan blood, bile, and urine.

Cancer Chemother Pharmacol ; –82 PubMed CrossRef Google ScholarCited by: 5.